Definition of Amniotic Membrane

The amnion which is also known as the Amniotic membrane is the innermost layer of the placenta which contains a significant number of essential growth factors and cytokines which is helpful for the human body. Amniotic membrane is widely used as a dressing or graft in different surgical specialties due to its ability to promote quicker wound healing. Amniotic membranes are being widely used in eye surgery as a biological bandage to heal or replace damaged eye tissue.

Global Amniotic Market: Key Insights

Global Amniotic Membrane Market Highlights Over 2023 - 2035

The global amniotic membrane market is estimated to garner a revenue of USD 3 Billion by the end of 2035 by growing at a CAGR of ~5% over the forecast period, i.e., 2023 – 2035. Further, the market generated a revenue of USD 1 Billion in the year 2023. The growth of the market can be attributed to a rise in the number of burn cases, surgeries, and increasing awareness of the potential of amniotic membranes in various medical procedures. An estimated 180,000 burn-related deaths occur all over the world every year, according to the World Health Organization (WHO). Moreover, the amniotic membrane is used as a biological dressing in the treatment of burns, thus expanding its market size.

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Amniotic Membrane (AM) or amnion is a thin membrane on the inside of the fetal placenta. It is harvested in a sterile environment from the placental tissue obtained during elective cesarean sections. There has been an upward trend in transplanting amniotic membranes to be used in reconstructive surgical procedures like ocular surface reconstruction, because of their anti-inflammatory, anti-bacterial, and anti-viral nature. Moreover, it is also used as a scaffolding material in tissue engineering applications such as skin grafts because of its capability to heal wounds and regenerate tissues. With the advancement in medical research and development, the amniotic membrane is used as a basement membrane substitute for the treatment of dry eyes. Nearly, 5 million people aged 50 or above in the United States have dry eyes.

Global Amniotic Membrane Market: Growth Drivers and Challenges

Growth Drivers

• Increase in the Number of Trauma Cases –The use of amniotic membranes in the treatment of trauma cases such as road accidents is anticipated to drive the growth of the global amniotic membrane market. As per the World Health Organization, between 20 to 50 million people suffer from non-fatal injuries owing to road accidents.

• Increased Use in Ophthalmic Surgeries – Amniotic membrane is highly used in ophthalmological procedures like ocular surface reconstruction, treating corneal ulcers, bullous keratopathy, and glaucoma surgeries. Moreover, the Amniotic membrane (AM) is used in the treatment of glaucoma. Hence, it is expected to surge the growth of the global amniotic membrane market. As per the data provided by the Centers for Disease Control and Prevention in 2020, approximately 3 million Americans have glaucoma, which is believed to be the second leading cause of blindness worldwide.

• Increase in Demand for Reconstructive Surgeries – The use of amniotic membranes in reconstructive surgeries reduces scarring, promotes faster healing, and reduces the risk of infections. Hence, it is anticipated to drive the growth of the global amniotic membrane market. As per the American Society of Plastic Surgeons, approximately 6.8 million reconstructive surgeries were undertaken in the year 2020 that is representing a 3 percent increase from the previous year 2019.

• Expansion of Geriatric Population- Disorders of the eyes like glaucoma and dry eye exacerbate with age, increasing the demand for amniotic membranes for ocular reconstruction purposes. As per the World Health Organization projection, the world’s aging population will nearly double from 12% in 2015 to 22% in 2050.

• Rise in Sports Injuries – Amniotic membrane is used in the treatment of soft tissue injuries which are common in sports and occur as a result of trauma or overuse. Therefore, it is expected to drive the growth of the global amniotic membrane market during the forecast period. It is estimated that more than 3 million injuries occur in youth sports every year.

Challenges

• Lack of Skilled Professionals with the Knowhow of Extraction and Transplantation of Amniotic Membrane

• Lack of Standardized Guidelines to Carry Out Amniotic Membrane-Related Procedures

• High Cost Associated with the Extraction, Storage, and Transplantation of Amniotic Membrane-High cost of extracting amniotic membrane challenges the market. The process requires a lot of time and patience which includes a long procedure and involves a high cost.

The global amniotic membrane market is segmented and analyzed for demand and supply by product type into lyophilized and cryopreserved amniotic membranes. Out of which, the Cryopreserved amniotic membranes segment holds the largest revenue share over the forecast period and will continue to do so, with its rampant use in ophthalmic surgeries. Studies show that it can effectively control inflammation in HSV keratitis, which is the leading cause of blindness. Moreover, as per the American Academy of Ophthalmology, there is an increasing incidence of HSV Keratitis accounting for 1.5 million cases each year worldwide. Therefore, the amniotic membrane is well-protected with cryopreserving as it keeps the histological and biological properties of the amniotic membrane intact and is anticipated to drive the growth of the cryopreserved amniotic membranes in the market.

Global Amniotic Membrane Market Regional Synopsis

Regionally, the global amniotic membrane market is categorized into five major regions including North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa regions. Amongst these, the market in the North America region is projected to hold the largest market share by the end of 2031 owing to the aging population requiring various eye surgeries, the presence of a large number of key market players, and advanced healthcare infrastructure. As per the National Eye Institute, around 16 million Americans suffer from an affliction called Dry Eye Disease (DED).

The Asia Pacific region is expected to grow at a fast pace during the forecast period, as a result of its high population growth, rising burn incidences, and increased spending on Reconstructive surgeries. The versatility and efficacy of amniotic membranes in burn-wound management make it a viable market during the forecast period. For Instance, over a million people suffer from moderate to severe burns every year in India.

Market Segmentation

Our in-depth analysis of the global amniotic membrane market includes the following segments:

Key Companies Dominating the Global Amniotic Membrane Market

Our report has covered detailed company profiling comprising company overview, business strategies, key product offerings, financial performance, key performance indicators, risk analysis, recent developments, regional presence, and SWOT analysis among other notable indicators for competitive positioning. Some of the prominent industry leaders in the global amniotic membrane market that are included in our report are MIMEDX, Inc., Skye Biologics Holdings, LLC, Katena Products, Inc., Amnio Technology, LLC, Applied Biologics LLC, Integra LifeSciences Corporation, Human Regenerative Technologies, LLC, Stryker, Organogenesis Inc., BioTissue, Inc., and others.

Global Amniotic Membrane Market: Latest Developments

• June 15, 2022: MIMEDX, Inc. announced a collaboration with Nordic Bioscience Clinical Development A/S (NBCD), to analyze the potential of the micronized dehydrated Human Amnion Chorion Membrane (mdHACM) in curbing the progression of Osteoarthritis.

• September 17, 2021: Amnio Technology, LLC   was awarded a Patent by the United States Patent and Trademark Office for Amniotic Allografts, called the “Enriched Multilayer Amnion Derived Tissue Graft”.

Geography Analysis:

The report further discusses the market opportunity, compound annual growth rate (CAGR) growth rate, competition, new technology innovations, market players analysis, government guidelines, export and import (EXIM) analysis, historical revenues, future forecasts etc. in the following regions and/or countries:

• North America (U.S. & Canada) Market Size, Y-O-Y Growth, Market Players Analysis & Opportunity Outlook
• Latin America (Brazil, Mexico, Argentina, Rest of Latin America) Market Size, Y-O-Y Growth & Market Players Analysis & Opportunity Outlook
• Europe (U.K., Germany, France, Italy, Spain, Hungary, Belgium, Netherlands & Luxembourg, NORDIC(Finland, Sweden, Norway, Denmark), Ireland, Switzerland, Austria, Poland, Turkey, Russia, Rest of Europe), Poland, Turkey, Russia, Rest of Europe) Market Size, Y-O-Y Growth Market Players Analys  & Opportunity Outlook
• Asia-Pacific (China, India, Japan, South Korea, Singapore, Indonesia, Malaysia, Australia, New Zealand, Rest of Asia-Pacific) Market Size, Y-O-Y Growth & Market Players Analysis & Opportunity Outlook
• Middle East and Africa  (Israel, GCC (Saudi Arabia, UAE, Bahrain, Kuwait, Qatar, Oman), North Africa, South Africa, Rest of Middle East and Africa) Market Size, Y-O-Y Growth Market Players Analysis & Opportunity Outlook

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